Modified PEG-Lipids Enhance the Nasal Mucosal Immune Capacity of Lipid Nanoparticle mRNA Vaccines
Background/Objectives: Omicron, the predominant variant of SARS-CoV-2, exhibits strong immune-evasive properties, leading to the reduced efficacy of existing vaccines.Consequently, the development of versatile vaccines is imperative.Intranasal mRNA vaccines offer convenient administration and have the potential to enhance mucosal immunity.However,